A Florida Keys road trip from Miami is one of the easiest and most scenic short getaways in the United States. In just 1–2 days, you can drive the iconic Overseas Highway, stop at Key Largo and Islamorada, and even reach Key West if time allows. This updated 2026 guide covers the best route, must-see stops, where to stay, and practical tips for first-time visitors.
Florida Keys Road Trip Route from Miami
A Florida Keys road trip from Miami follows the famous Overseas Highway (US-1), stretching over 100 miles of bridges and turquoise waters. The drive itself is the highlight, with ocean views on both sides and easy stops along the way. Most travelers start early from Miami, reach Key Largo in about 1.5 hours, and continue south through Islamorada toward Marathon or Key West. If you’re planning a Florida getaway beyond the Keys, check out our Miami Winter Travel Guide (2025–2026) for seasonal tips, top beaches, and city highlights.
🚗 Day 1: Miami to Key Largo & Islamorada
Start your journey early and head toward Key Largo:
- Snorkel or kayak at John Pennekamp Coral Reef State Park
- Stop at Mrs. Mac’s Kitchen for key lime pie 🍋🥧
Next up, explore Islamorada:
- Chill at Morada Bay Beach Café
- Visit Theater of the Sea for a dolphin show 🐬
🛏️ Where to Stay in the Keys
Stay overnight in Islamorada or Marathon for dreamy views:
- View hotels and resorts in Islamorada on Expedia
- Check Key Largo accommodations and prices on Expedia
🌅 Day 2: Sunrise to Key West (Optional)
If you have more time, drive down to Key West:
- Visit Southernmost Point
- Snap pics on Duval Street
- Eat fresh seafood at Latitudes Restaurant
Or head back slowly with beach breaks on Big Pine Key or Bahia Honda State Park.
For snorkeling conditions and park updates, check the official John Pennekamp Coral Reef State Park website.
Florida Keys Road Trip Tips for First-Time Visitors
If this is your first Florida Keys road trip from Miami, plan fuel stops in advance, especially beyond Islamorada. Start your drive early to avoid traffic, carry reef-safe sunscreen, and book accommodations ahead during peak seasons. Cell service is reliable, but having offline maps helps when exploring smaller keys.
Best Time to Do a Florida Keys Road Trip
The best time for a Florida Keys road trip from Miami is between November and April when the weather is dry and pleasant. Summer offers fewer crowds but comes with heat and occasional storms. Spring and early winter are ideal for snorkeling, beach stops, and relaxed driving.
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